Xinyin Ganzhu Jing is a comprehensive medical work of Hejian school,which plays an connecting link between the preceding and the following role in inheriting and spreading LIU Wansu's academic thought.There are several editions of this book,but the description of the collection purpose of various libraries is ambiguous,and the academic circles have not sorted out the origin of its edition.This paper mainly uses the comparative method,combined with bibliographic literature,to make a detailed comparison and textual research on the known and seen editions,reveals the edition characteristics and successive inheritance relationship of various editions,and also points out the difference and relationship between the newly discovered YE liangyu's engraving and ZHAO Ying's engraving.