首页|不同针灸方法对慢性疲劳综合征大鼠运动能力及细胞因子的影响

不同针灸方法对慢性疲劳综合征大鼠运动能力及细胞因子的影响

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目的:探讨不同针灸方法对慢性疲劳综合征(CFS)大鼠运动能力及细胞因子的影响.方法:64只SD大鼠随机分为空白对照组、模型组、毫针1组、毫针2组、电针1组、电针2组、艾灸1组、艾灸2组,每组8只.采用慢性多重复合应激法制备CFS大鼠模型.毫针1组、电针1组、艾灸1组选取百会、足三里(双)、三阴交(双)穴,分别采用毫针、电针、艾灸治疗,每天1次,连续治疗18 d.毫针2组、电针2组、艾灸2组操作同1组,隔天1次,连续治疗9次.治疗结束后,记录大鼠负重力竭游泳时间以测评大鼠运动能力,检测大鼠血清IL-4、IL-10、IFN-γ、TNF-α分泌水平.结果:造模完成后,模型组大鼠力竭游泳时间较空白对照组缩短(P<0.05),针灸各组治疗后大鼠力竭游泳时间均较模型组长(P<0.05),其中艾灸1组大鼠力竭游泳时间最长;模型组大鼠血清IL-4、IL-10水平较空白对照组升高,IFN-γ、TNF-α水平较空白对照组降低.针灸治疗后,各组IL-4、IL-10水平均下降,IFN-γ、TNF-α水平均上升,其中艾灸1组对IL-4、IL-10的改善优于其他治疗组.结论:毫针、电针、艾灸均可延长大鼠力竭游泳时间,调节细胞因子的分泌水平,以艾灸每日1次的效果为最佳.
Effect of Different Acupuncture Methods on Motor Function and Cytokines of Rats with Chronic Fatigue Syndrome
Objective:To study the effect of different acupuncture methods on motor function and cytokines of rats with chronic fatigue syndrome.Methods:Sixty-four SD rats were randomly divided into blank group,model group,acupuncture group 1,acupuncture group 2,electroacupuncture group 1,electroacupuncture group 2,moxibustion group 1 and moxibustion group 2.It was through chronic multiple compound stress method to set up the CFS model of rats,Acupuncture group 1,electroacupuncture group 1,moxibustion group 1,selected Baihui,Zusanli(double)and Sanyinjiao(double)points,respectively using acupuncture,electroacupuncture,moxibustion treatment,once a day for 18 days.Acupuncture group 2,electroacupuncture group 2 and moxibustion group 2 were the same as group 1,once every other day for 9 treatments.After the treatment,detect motor function of the rats and the serum secretion levels of IL-4、IL-10、IFN-γ、TNF-α.Results:Exhaustion swimming time in the model group was shorter than blank group(P<0.05),each group after treatment was longer than the model group(P<0.05),among them,moxibustion group 1 is the longest;the levels of IL-4 and IL-10 in the model group is increased and the levels of IFN-γ and TNF-α is decreased than the blank group.After treatment,the levels of IL-4 and IL-10 decreased and the levels of IFN-γ and TNF-α increased in all groups,moxibustion group 1 improved IL-4 and IL-10 better than the other treatment groups.Conclusion:Acupuncture,electroacupuncture and moxibustion can improve the motor function and immune function of CFS rats,among which,moxibustion once a day has the best effect.

AcupunctureElectroacupunctureMoxibustionChronic Fatigue SyndromeCytokines

刘长征、雷波

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宜春学院美容医学院 江西 宜春 336000

毫针 电针 艾灸 慢性疲劳综合征 细胞因子

2024

江西中医药大学学报
江西中医学院

江西中医药大学学报

影响因子:0.575
ISSN:2095-7785
年,卷(期):2024.36(5)