Effects of Stroke No.1 Formula Combined with Butylphthalide on Neurological Function and Vascular Endothelial Function in Patients with Acute Cerebral Infarction
Objective:To investigate the effects of Stroke No.1 Formula combined with butylphthalide on neurological function indexes and vascular endothelial function indexes in patients with acute cerebral infarction(ACI).Methods:97 patients with ACI treated in Jiangxi Integrated Hospital of Traditional Chinese and Western Medicine from October 2021 to June 2023 were selected and divided into control group(n=48)and observation group(n=49)according to randomized numerical method.The control group was treated with butylphthalide alone,and the observation group was treated with Stroke No.1 Formula on this basis,and both groups were treated for 2 weeks.The clinical efficacy,neurological function,vascular endothelial function and inflammatory response of the two groups were compared.Results:Comparing the total clinical efficacy rate of the 2 groups,the observation group(93.88%)was higher than that of the control group(79.17%),and the difference was statistically significant(P<0.05).After treatment,the National Institutes of Health Stroke Scale scores of the 2 groups were reduced,and the observation group was lower than the control group,and the differences were statistically significant(P<0.05);nitric oxide(NO)was elevated in the 2 groups,and endothelin-1(ET-1)was reduced in the 2 groups,and NO was higher than the control group in the observation group,and ET-1 was lower than the control group,and the differences were statistically significant(P<0.05);and C-reactive protein in the 2 groups,C-reactive protein,tumor necrosis factor-α and interleukin-6 were all reduced in the two groups,and the above indexes in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion:The efficacy of Stroke No.1 Formula combined with butylphthalide in the treatment of ACI is precise,which can improve the vascular endothelial function,reduce inflammatory reaction,and improve the neurological function.
Acute Cerebral InfarctionStroke One FormulaButylphthalideNeurological FunctionVascular Endothelial FunctionInflammatory Reaction
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