Analysis of the Mechanism of Chaihu Longgu Muli Decoction in the Treatment of Depression and Systematic Evaluation of its Efficacy
Depression belongs to the category of"depression syndrome"in traditional Chinese medicine,with liver depression as the pathogenesis.Chaihu Longgu Muli Decoction is a kind of Chaihu formula,which has the effect of soothing the liver,relieving depression,calming nerves and calming convulsions.It is suitable for the treatment of depression and has a good effect.This article collected the clinical and experimental research literature of Chaihu Longgu Muli Decoction in the treatment of depression,combined with network pharmacology research to analyze its mechanism of action.It found that Chaihu Longgu Muli Decoction plays an antidepressant role by participating in the brain derived neurotrophic factor signaling pathway,cyclic adenosine phosphate pathway and mitogen activated protein kinase pathway in the central hippocampus.Meta-analysis was carried out on the clinical control study of Chaihu Longgu Muli Decoction in the treatment of depression,and its efficacy was evaluated.The results showed that the treatment effect of Chaihu Longgu Muli Decoction or Chaihu Longgu Muli Decoction combined with antidepressants in patients with depression[OR=2.68,95%CI(1.93,3.72)]and the reduction of HAMD score of patients[MD=1.19,95%CI(-2.21,4.58)]were superior to the treatment of antidepressants alone.
DepressionChaihu Longgu Muli DecoctionMechanism of ActionSignal Transduction PathwayMeta-analysis
NETL
NSTL
万方数据
