首页|Hydrogen sulfide-induced post-translational modification as a potential drug target

Hydrogen sulfide-induced post-translational modification as a potential drug target

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Hydrogen sulfide(H2S)is one of the three known gas signal transducers,and since its potential physiological role was reported,the literature on H2S has been increasing.H2S is involved in processes such as vasodilation,neurotransmission,angiogenesis,inflammation,and the prevention of ischemia-reperfusion injury,and its mechanism remains to be further stud-ied.At present,the role of post-translational processing of proteins has been considered as a possible mechanism for the involvement of H2S in a variety of physiological processes.Current studies have shown that H2S is involved in S-sulfhydration,phosphorylation,and S-nitrosylation of proteins,etc.This paper focuses on the effects of protein modification involving H2S on physiologicaland pathological processes,looking forward to providing guidance for subsequent research.

Hydrogen sulfideModificationPhosphorylationS-nitrosylationS-sulfhydration

Hao-Jie Chen、Lei Qian、Ke Li、Yang-Zhe Qin、Jing-Jing Zhou、Xin-Ying Ji、Dong-Dong Wu

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School of Basic Medical Sciences,Henan University,Kaifeng,Henan 475004,China

Henan International Joint Laboratory for Nuclear Protein Regulation,Henan University,Kaifeng,Henan 475004,China

Kaifeng Key Laboratory of Infection and Biological Safety,School of Basic Medical Sciences,Henan University,Kaifeng,Henan 475004,China

School of Stomatology,Henan University,Kaifeng,Henan 475004,China

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National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaTraining Program for Young Backbone Teachers of Institutions of Higher Learning in Henan Province,ChinaFoundation of Science & Technology Department of Henan Province,ChinaFoundation of Science & Technology Department of Henan Province,ChinaFoundation of Science & Technology Department of Henan Province,China

81802718816700882020GGJS038202102310480222102310490222102310495

2023

10.1016/j.gendis.2022.03.022

基因与疾病(英文)

基因与疾病(英文)

CSCD
ISSN：
年,卷(期)：2023.10(5)
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