首页|HIF-1α signaling:Essential roles in tumorigenesis and implications in targeted therapies
HIF-1α signaling:Essential roles in tumorigenesis and implications in targeted therapies
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The hypoxic microenvironment is an essential characteristic of most malignant tu-mors.Notably,hypoxia-inducible factor-1 alpha(HIF-1α)is a key regulatory factor of cellular adaptation to hypoxia,and many critical pathways are correlated with the biological activity of organisms via HIF-1α.In the intra-tumoral hypoxic environment,HIF-1α is highly expressed and contributes to the malignant progression of tumors,which in turn results in a poor prog-nosis in patients.Recently,it has been indicated that HIF-1α involves in various critical pro-cesses of life events and tumor development via regulating the expression of HIF-1α target genes,such as cell proliferation and apoptosis,angiogenesis,glucose metabolism,immune response,therapeutic resistance,etc.Apart from solid tumors,accumulating evidence has re-vealed that HIF-1α is also closely associated with the development and progression of hemato-logical malignancies,such as leukemia,lymphoma,and multiple myeloma.Targeted inhibition of HIF-1α can facilitate an increased sensitivity of patients with malignancies to relevant ther-apeutic agents.In the review,we elaborated on the basic structure and biological functions of HIF-1α and summarized their current role in various malignancies.It is expected that they will have future potential for targeted therapy.
Yan Zhao、Cheng Xing、Yating Deng、Can Ye、Hongling Peng
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Department of Hematology,The Second Xiangya Hospital,Central South University,Changsha,Hunan 410011,China
Hunan Key Laboratory of Tumor Models and Individualized Medicine,The Second Xiangya Hospital,Central South University,Changsha,Hunan 410011,China
Hunan Engineering Research Center of Cell Immunotherapy for Hematopoietic Malignancies,The Second Xiangya Hospital,Central South University,Changsha,Hunan 410011,China
国家自然科学基金湖南省自然科学基金Scientific Program of the Health Commission of Hunan Province(China)
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