首页|The role of m6A RNA methylation in autoimmune diseases:Novel therapeutic opportunities
The role of m6A RNA methylation in autoimmune diseases:Novel therapeutic opportunities
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N6-methyladenosine(m6A)modifications,as one of the most common forms of in-ternal RNA chemical modifications in eukaryotic cells,have gained increasing attention in recent years.The m6A RNA modifications exert various crucial roles in various biological pro-cesses,such as embryonic development,neurogenesis,circadian rhythms,and tumorigenesis.Recent advances have highlighted that m6A RNA modification plays an important role in im-mune response,especially in the initiation and progression of autoimmune diseases.In this re-view,we summarized the regulatory mechanisms of m6A methylation and its biological functions in the immune system and mainly focused on recent progress in research on the po-tential role of m6A RNA methylation in the pathogenesis of autoimmune diseases,thus providing possible biomarkers and potential targets for the prevention and treatment of auto-immune diseases.
The First Clinical Medical College,Shandong University of Traditional Chinese Medicine,Jinan,Shandong 250013,China
Department of Neurology,The First Affiliated Hospital of Shandong First Medical University &Shandong Provincial Qianfoshan Hospital,Shandong Institute of Neuroimmunology,Shandong Key Laboratory of Rheumatic Disease and Translational Medicine,Jinan,Shandong 250013,China
Department of Gastroenterology,Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200233,China
国家自然科学基金Academic promotion programme of Shandong First Medical University(China)
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