首页|Recombinant adeno-associated virus 8 vector in gene therapy:Opportunities and challenges

Recombinant adeno-associated virus 8 vector in gene therapy:Opportunities and challenges

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In recent years,significant breakthroughs have been made in the field of gene ther-apy.Adeno-associated virus(AAV)is one of the most promising gene therapy vectors and a powerful tool for delivering the gene of interest.Among the AAV vectors,AAV serotype 8(AAV8)has attracted much attention for its efficient and stable gene transfection into specific tissues.Currently,recombinant AAV8 has been widely used in gene therapy research on a va-riety of diseases,including genetic diseases,cancers,autoimmune diseases,and viral diseases.This paper reviewed the applications and challenges of using AAV8 as a vector for gene ther-apy,with the aim of providing a valuable resource for those pursuing the application of viral vectors in gene therapy.

AAV8Adeno-associated virusGene therapyPrimatesRecombinantRodents

Liyuan Zhao、Zixuan Yang、Minhui Zheng、Lei Shi、Mengyun Gu、Gang Liu、Feng Miao、Yan Chang、Fanghua Huang、Naping Tang

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Anhui University of Traditional Chinese Medicine,Hefei,Anhui 230000,China

Yangtze Delta Drug Advanced Research Institute,Yangtze Delta Pharmaceutical College,Nantong,Jiangsu 226133,China

InnoStar Bio-tech Nantong Co.,Ltd.,Nantong,Jiangsu 226133,China

Shanghai Innostar Bio-Technology Co.,Ltd,China State Institute of Pharmaceutical Industry,Shanghai 201203,China

Center for Drug Evaluation,National Medical Products Administration,Beijing 100022,China

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2024

10.1016/j.gendis.2023.02.010

基因与疾病(英文)

基因与疾病(英文)

ISSN：
年,卷(期)：2024.11(1)
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