Structure,ligands,and roles of GPR126/ADGRG6 in the development and diseases

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外文摘要：Adhesion G protein-coupled receptors(aGPCRs)are the second largest diverse group within the GPCR superfamily,which play critical roles in many physiological and patho-logical processes through cell-cell and cell-extracellular matrix interactions.The adhesion GPCR Adgrg6,also known as GPR126,is one of the better-characterized aGPCRs.GPR126 was previously found to have critical developmental roles in Schwann cell maturation and its mediated myelination in the peripheral nervous system in both zebrafish and mammals.Current studies have extended our understanding of GPR126-mediated roles during develop-ment and in human diseases.In this review,we highlighted these recent advances in GPR126 in expression profile,molecular structure,ligand-receptor interactions,and associ-ated physiological and pathological functions in development and diseases.

外文关键词：

Adhesion G protein-coupled receptorFunctionGPR126/Adgrg6LigandStructure

作者：

Qi Li、Anran Huo、Mengqi Li、Jiali Wang、Qiao Yin、Lumiao Chen、Xin Chu、Yuan Qin、Yuwan Qi、Yang Li、Hengxiang Cui、Qifei Cong

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作者单位：

Institute of Neuroscience and Jiangsu Key Laboratory of Neuropsychiatric Diseases,Soochow University,Suzhou,Jiangsu 215123,China

Department of Neurology and Clinical Research Center of Neurological Disease,The Second Affiliated Hospital of Soochow University,Suzhou,Jiangsu 215004,China

Department of Nephrology,The Second Affiliated Hospital of Soochow University,Suzhou,Jiangsu 215004,China

Department of Emergency Center,The Second Affiliated Hospital of Nantong University,Nantong,Jiangsu 226001,China

Department of Neurology,Huzhou Central Hospital,The Affiliated Huzhou Hospital,Zhejiang University School of Medicine,Huzhou,Zhejiang 313000,China

Institute of Neuroscience,State Key Laboratory of Neuroscience,CAS Center for Excellence in Brain Science and Intelligence Technology,Chinese Academy of Sciences,Shanghai 200031,China

Shanghai Key Laboratory of Psychotic Disorders,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China

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基金：

国家自然科学基金江苏省自然科学基金Suzhou Medical and Health Technology Innovation Project(China)startup fund of Soochow University(China)startup fund of Soochow University(China)Clinical Research Center of Neurological Disease in The Second Affiliated Hospital of Soochow University,ChinaNantong Municipal Health and Family Planning Commission(China)

项目编号：

32200778BK20220494SKY2022107NH21500221NH21500122ND2022A04QA2021017

出版年：

2024

DOI：

10.1016/j.gendis.2023.02.016

基因与疾病(英文)

ISSN：

年,卷(期)：2024.11(1)

参考文献量84