首页|Cancer organoids:A platform in basic and translational research

Cancer organoids:A platform in basic and translational research

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
An accumulation of previous work has established organoids as good preclinical models of human tumors,facilitating translation from basic research to clinical practice.They are changing.the paradigm of preclinical cancer research because they can recapitulate the heterogeneity and pathophysiology of human cancers and more closely approximate the com-plex tissue environment and structure found in clinical tumors than in vitro cell lines and an-imal models.However,the potential applications of cancer organoids remain to be comprehensively summarized.In the review,we firstly describe what is currently known about cancer organoid culture and then discuss in depth the basic mechanisms,including tumorigen-esis and tumor metastasis,and describe recent advances in patient-derived tumor organoids(PDOs)for drug screening and immunological studies.Finally,the present challenges faced by organoid technology in clinical practice and its prospects are discussed.This review high-lights that organoids may offer a novel therapeutic strategy for cancer research.

Drug assaysImmunotherapyMechanism researchOrganoidsPrecision medicine

Xin Ma、Qin Wang、Guozheng Li、Hui Li、Shouping Xu、Da Pang

展开 >

Department of Breast Surgery,Harbin Medical University Cancer Hospital,Harbin,Heilongjiang 150081,China

Sino-Russian Medical Research Center,Harbin Medical University Cancer Hospital,Harbin,Heilongjiang 150081,China

Heilongjiang Academy of Medical Sciences,Harbin,Heilongjiang 150086,China

Department of Pharmacology(The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China),College of Pharmacy of Harbin Medical University,Harbin,Heilongjiang 150086,China

展开 >

Project Nn10 of Harbin Medical University Cancer Hospital,Heilongjiang,China国家自然科学基金国家自然科学基金国家自然科学基金国家自然科学基金国家自然科学基金Outstanding Youth Project of Heilongjiang Provincial Natural Science Foundation,Heilongjiang,ChinaDistinguished Young Scholars of Harbin Medical University Cancer Hospital,Heilongjiang,ChinaYong Elite Training Foundation Grant of Harbin Medical University Cancer Hospital,Heilongjiang,ChinaHaiyan Fund Project of Harbin Medical University Cancer Hospital,Heilongjiang,China

Nn102017-028197270681872149821732358207290482103325YQ2019H027JCQN2018-03JY2016-02JJMS 2022-17

2024

10.1016/j.gendis.2023.02.052

基因与疾病(英文)

基因与疾病(英文)

ISSN：
年,卷(期)：2024.11(2)
  • 204