首页|The generation and use of animal models of osteosarcoma in cancer research

The generation and use of animal models of osteosarcoma in cancer research

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Osteosarcoma is the most common malignant bone tumor affecting children and adolescents.Currently,the most common treatment is surgery combined with neoadjuvant chemotherapy.Although the survival rate of patients with osteosarcoma has improved in recent years,it remains poor when the tumor(s)progress and distant metastases develop.Therefore,better animal models that more accurately replicate the natural progression of the disease are needed to develop improved prognostic and diagnostic markers,as well as tar-geted therapies for both primary and metastatic osteosarcoma.The present review described animal models currently being used in research investigating osteosarcoma,and their charac-teristics,advantages,and disadvantages.These models may help elucidate the pathogenic mechanism(s)of osteosarcoma and provide evidence to support and develop clinical treatment strategies.

Animal modelCancerOsteosarcomaPathogenic mechanismTranslational research

Feifei Pu、Haoyu Guo、Deyao Shi、Fengxia Chen、Yizhong Peng、Xin Huang、Jianxiang Liu、Zhicai Zhang、Zengwu Shao

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Department of Orthopedics,Wuhan Hospital of Traditional Chinese and Western Medicine(Wuhan No.1 Hospital),Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430022,China

Department of Orthopedics,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430022,China

Department of Radiation and Medical Oncology,Zhongnan Hospital,Wuhan University,Wuhan,Hubei 430071,China

Hubei Cancer Clinical Study Center,Zhongnan Hospital,Wuhan University,Wuhan,Hubei 430071,China

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国家自然科学基金国家自然科学基金国家自然科学基金国家自然科学基金中国博士后科学基金湖北省自然科学基金

822745598190423182072978820729792020M6723692020CFB861

2024

10.1016/j.gendis.2022.12.021

基因与疾病(英文)

基因与疾病(英文)

ISSN：
年,卷(期)：2024.11(2)
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