The journey towards physiology and pathology:Tracing the path of neuregulin 4

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外文摘要：Neuregulin 4(Nrg4),an epidermal growth factor(EGF)family member,can bind to and activate the ErbB4 receptor tyrosine kinase.Nrg4 has five different isoforms by alternative splicing and performs a wide variety of functions.Nrg4 is involved in a spectrum of physiolog-ical processes including neurobiogenesis,lipid metabolism,glucose metabolism,thermogene-sis,and angiogenesis.In pathological processes,Nrg4 inhibits inflammatory factor levels and suppresses apoptosis in inflammatory diseases.In addition,Nrg4 could ameliorate obesity,in-sulin resistance,and cardiovascular diseases.Furthermore,Nrg4 improves non-alcoholic fatty liver disease(NAFLD)by promoting autophagy,improving lipid metabolism,and inhibiting cell death of hepatocytes.Besides,Nrg4 is closely related to the development of cancer,hyperthy-roidism,and some other diseases.Therefore,elucidation of the functional role and mecha-nisms of Nrg4 will provide a clearer view of the therapeutic potential and possible risks of Nrg4.

外文关键词：

AngiogenesisCardiovascular diseasesInflammationInsulin resistanceLipid and glucose metabolismNAFLDNeurobiogenesisObesity

作者：

Min Chen、Jieying Zhu、Hongyang Luo、Wangjing Mu、Liang Guo

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作者单位：

School of Exercise and Health and Shanghai Frontiers Science Research Base of Exercise and Metabolic Health,Shanghai University of Sport,Shanghai 200438,China

基金：

Program for Overseas High-level Talents at Shanghai Institutions of Higher Learning(China)国家自然科学基金国家自然科学基金

项目编号：

20221003207075131871435

出版年：

2024

DOI：

10.1016/j.gendis.2023.03.021

基因与疾病(英文)

ISSN：

年,卷(期)：2024.11(2)

参考文献量94