首页|The Wnt-dependent and Wnt-independent functions of BCL9 in development,tumorigenesis,and immunity:Implications in therapeutic opportunities

The Wnt-dependent and Wnt-independent functions of BCL9 in development,tumorigenesis,and immunity:Implications in therapeutic opportunities

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B-cell CLL/lymphoma 9(BCL9)is considered a key developmental regulator and a well-established oncogenic driver in multiple cancer types,mainly through potentiating the Wnt/β-catenin signaling.However,increasing evidences indicate that BCL9 also plays multiple Wnt-independent roles.Herein,we summarized the updates of the canonical and non-canon-ical functions of BCL9 in cellular,physiological,or pathological processes.Moreover,we also concluded that the targeted inhibitors disrupt the interaction of β-catenin with BCL9 reported recently.

BCL9DevelopmentImmunityMultifaceted functionsTherapeutic targetTumorigenesis

Minjie Wu、Heng Dong、Chao Xu、Mengqing Sun、Haojin Gao、Fangtian Bu、Jianxiang Chen

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College of Pharmacy and Department of Hepatology,Institute of Hepatology and Metabolic Diseases,The Affiliated Hospital of Hangzhou Normal University,Hangzhou Normal University,Hangzhou,Zhejiang 311121,China

Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines,Engineering Laboratory of Development and Application of Traditional Chinese Medicines,Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province,Hangzhou Normal University,Hangzhou,Zhejiang 311121,China

Laboratory of Cancer Genomics,Division of Cellular and Molecular Research,National Cancer Centre,Singapore 169610,Singapore

Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines,Engineering Laboratory of Development and Application of Traditional Chinese Medicines,Collaborative Innovation Center

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浙江省自然科学基金"Pioneer"and"Leading Goose"Research and Development Program of Zhejiang,China国家自然科学基金国家自然科学基金浙江省自然科学基金Startup Grant of Hangzhou Normal University(China)

LR21H1600012022C030048207264682104214LQ22H1600164275C50222204072

2024

10.1016/j.gendis.2023.03.012

基因与疾病(英文)

基因与疾病(英文)

ISSN：
年,卷(期)：2024.11(2)
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