首页|Signaling pathways governing the behaviors of leukemia stem cells

Signaling pathways governing the behaviors of leukemia stem cells

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Leukemia is a malignancy in the blood that develops from the lymphatic system and bone marrow.Although various treatment options have been used for different types of leuke-mia,understanding the molecular pathways involved in the development and progression of leukemia is necessary.Recent studies showed that leukemia stem cells(LSCs)play essential roles in the pathogenesis of leukemia by targeting several signaling pathways,including Notch,Wnt,Hedgehog,and STAT3.LSCs are highly proliferative cells that stimulate tumor initiation,migration,EMT,and drug resistance.This review summarizes cellular pathways that stimulate and prevent LSCs'self-renewal,metastasis,and tumorigenesis.

LeukemiaLeukemia stem cellsPathogenesisSignaling pathwaysStem cells

Shirin Azizidoost、Ava Nasrolahi、Mohadeseh Sheykhi-Sabzehpoush、Amir Anbiyaiee、Seyed Esmaeil Khoshnam、Maryam Farzaneh、Shahab Uddin

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Atherosclerosis Research Center,Ahvaz Jundishapur University of Medical Sciences,Ahvaz 6193673111,Iran

Infectious Ophthalmologic Research Center,Ahvaz Jundishapur University of Medical Sciences,Ahvaz 6193673111,Iran

Department of Laboratory,Imam Khomeini Hospital Complex,Tehran University of Medical Sciences,Tehran 2193672411,Iran

Department of Surgery,School of Medicine,Ahvaz Jundishapur University of Medical Sciences,Ahvaz 6193673111,Iran

Persian Gulf Physiology Research Center,Medical Basic Sciences Research Institute,Ahvaz Jundishapur University of Medical Sciences,Ahvaz 6193673111,Iran

Fertility,Infertility and Perinatology Research Center,Ahvaz Jundishapur University of Medical Sciences,Ahvaz 6193673111,Iran

Translational Research Institute and Dermatology Institute,Academic Health System,Hamad Medical Corporation,Doha 3050,Qatar

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2024

10.1016/j.gendis.2023.01.008

基因与疾病(英文)

基因与疾病(英文)

ISSN：
年,卷(期)：2024.11(2)
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