首页|Oncogenic MORC2 in cancer development and beyond

Oncogenic MORC2 in cancer development and beyond

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Microrchidia CW-type zinc finger 2(MORC2)is a member of the MORC superfamily of nuclear proteins.Growing evidence has shown that MORC2 not only participates in gene tran-scription and chromatin remodeling but also plays a key in human disease and tumor develop-ment by regulating the expression of downstream oncogenes or tumor suppressors.The present review provides an updated overview of MORC2 in the aspect of cancer hallmark and therapeutic resistance and summarizes its upstream regulators and downstream target genes.This systematic review may provide a favorable theoretical basis for emerging players of MORC2 in tumor development and new insight into the potential clinical application of basic science discoveries in the future.

Cancer developmentHallmarks of cancerMORC2Therapeutic targetTreatment resistance

Shan Zhang、Ayao Guo、Huan Wang、Jia Liu、Chenshuang Dong、Junyi Ren、Guiling Wang

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Key Laboratory of Cell Biology,Department of Cell Biology,Ministry of Public Health and Key Laboratory of Medical Cell Biology,Ministry of Education,China Medical University,Shenyang,Liaoning 110122,China

Department of Breast Surgery,The First Affiliated Hospital of China Medical University,Shenyang,Liaoning 110001,China

国家自然科学基金国家自然科学基金Foundation Committee of Basic Research of Liaoning Province,ChinaApplication Foundation Plan Project of Liaoning Provincial Department of Science and Technology(China)

8157261181828009UKMZ202212052023JH2/101300012

2024

10.1016/j.gendis.2023.05.010

基因与疾病(英文)

基因与疾病(英文)

ISSN：
年,卷(期)：2024.11(2)
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