首页|Crosstalk between glioblastoma and tumor microenvironment drives proneural-mesenchymal transition through ligand-receptor interactions

Crosstalk between glioblastoma and tumor microenvironment drives proneural-mesenchymal transition through ligand-receptor interactions

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Glioblastoma(GBM)is the most common intrinsic and aggressive primary brain tu-mor in adults,with a median survival of approximately 15 months.GBM heterogeneity is considered responsible for the treatment resistance and unfavorable prognosis.Proneural-mesenchymal transition(PMT)represents GBM malignant progression and recurrence,which might be a breakthrough to understand GBM heterogeneity and overcome treatment resis-tance.PMT is a complicated process influenced by crosstalk between GBM and tumor microen-vironment,depending on intricate ligand-receptor interactions.In this review,we summarize the autocrine and paracrine pathways in the GBM microenvironment and related ligand-recep-tor interactions inducing PMT.We also discuss the current therapies targeting the PMT-related autocrine and paracrine pathways.Together,this review offers a comprehensive understand-ing of the failure of GBM-targeted therapy and ideas for future tendencies of GBM treatment.

AutocrineGlioblastomaLigand-receptor interactionMicroenvironmentParacrineProneural-mesenchymal transition

Yancheng Lai、Xiaole Lu、Yankai Liao、Pei Ouyang、Hai Wang、Xian Zhang、Guanglong Huang、Songtao Qi、Yaomin Li

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Department of Neurosurgery,Institute of Brain Disease,Nanfang Hospital,Southern Medical University,Guangzhou,Guangdong 510515,China

Laboratory for Precision Neurosurgery,Nanfang Hospital,Southern Medical University,Guangzhou,Guangdong 510515,China

国家自然科学基金Science and Technology Projects in Guangzhou,Guangdong,ChinaCollege Students'Innovative Entrepreneurial Training Plan Program,China

82203368202201011008202112121201

2024

10.1016/j.gendis.2023.05.025

基因与疾病(英文)

基因与疾病(英文)

ISSN：
年,卷(期)：2024.11(2)
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