Department of Orthopedics,The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital,Ji'nan,Shandong 250014,China

Biomedical Sciences College & Shandong Medicinal Biotechnology Centre,Shandong First Medical University &Shandong Academy of Medical Sciences,Ji'nan,Shandong 250117,China

NHC Key Laboratory of Biotechnology Drugs(Shandong Academy of Medical Sciences),Ji'nan,Shandong 250117,China

Key Lab for Rare & Uncommon Diseases of Shandong Province,Ji'nan,Sha

Department of Orthopaedic Surgery,New York University Grossman School of Medicine,New York,NY 10003,USA

Department of Cell Biology,New York University Grossman School of Medicine,New York,NY 10016,USA