Department of Biomedicine and Prevention,University of Rome Tor Vergata,Rome 00133,Italy

Pediatric Clinical Research Center"Romeo ed Enrica Invernizzi",Department of Biomedical and Clinical Sciences,University of Milano,Milano 20157,Italy

Center of Functional Genomics and Rare Diseases,Department of Pediatrics,Buzzi Children's Hospital,Milano 20154,Italy

Department of Child Neurology and Psychiatry,IRCCS Mondino Foundation,Pavia 27100,Italy

Unit of Pediatric Neurology,C.O.A.L.A(Center for Diagnosis and Treatment of Leukodystrophies),Buzzi Children's Hospital,Milano 20154,Italy

Department of Biosciences,Biotechnologies and Environment,University of Bari"Aldo Moro",Bari 70125,Italy

Institute of Biomembranes,Bioenergetics and Molecular Biotechnologies(IBIOM),National Research Council(CNR),Bari 70126,Italy

Biostructures and Biosystems National Institute(INBB),Rome 00136,Italy Elisa Orecchini Present address.Institute of Biochemistry and Cell Biology,IBBC-CNR,Campus Adriano Buzzati Traverso,Rome 00015,Italy.