首页|Recent advances of mechanosensitive genes in vascular endothelial cells for the formation and treatment of atherosclerosis
Recent advances of mechanosensitive genes in vascular endothelial cells for the formation and treatment of atherosclerosis
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Atherosclerotic cardiovascular disease and its complications are a high-incidence disease worldwide.Numerous studies have shown that blood flow shear has a huge impact on the function of vascular endothelial cells,and it plays an important role in gene regulation of pro-inflammatory,pro-thrombotic,pro-oxidative stress,and cell permeability.Many impor-tant endothelial cell mechanosensitive genes have been discovered,including KLK10,CCN gene family,NRP2,YAP,TAZ,HIF-1α,NF-κB,FOS,JUN,TFEB,KLF2/KLF4,NRF2,and ID1.Some of them have been intensively studied,whereas the relevant regulatory mechanism of other genes remains unclear.Focusing on these mechanosensitive genes will provide new strategies for therapeutic intervention in atherosclerotic vascular disease.Thus,this article reviews the mechanosensitive genes affecting vascular endothelial cells,including classical pathways and some newly screened genes,and summarizes the latest research progress on their roles in the pathogenesis of atherosclerosis to reveal effective therapeutic targets of drugs and provide new insights for anti-atherosclerosis.
Shuyu Li、Zichen Xu、Yi Wang、Lizhao Chen、Xiangxiu Wang、Yanghao Zhou、Daoxi Lei、Guangchao Zang、Guixue Wang
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Key Laboratory of Biorheological Science and Technology of Ministry of Education,National and Local Joint Engineering Laboratory for Vascular Implants,Bioengineering College of Chongqing University,Chongqing 400030,China
College of Basic Medical Sciences,Chongqing Medical University,Chongqing 400016,China
Department of Neurosurgery,Doping Hospital,Army Medical Center of PLA,Army Medical University,Chongqing 400042,China
国家自然科学基金国家自然科学基金Chongqing Science and Technology Bureau(China)Joint Medical Research Project of Chongqing Science and Technology Bureau and Chongqing Health Commission(China)
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