首页|Microbiome and intestinal pathophysiology in post-acute sequelae of COVID-19

Microbiome and intestinal pathophysiology in post-acute sequelae of COVID-19

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Long COVID,also known for post-acute sequelae of COVID-19,describes the people who have the signs and symptoms that continue or develop after the acute COVID-19 phase.Long COVID patients suffer from an inflammation or host responses towards the virus approx-imately 4 weeks after initial infection with the SARS CoV-2 virus and continue for an unchar-acterized duration.Anyone infected with COVID-19 before could experience long-COVID conditions,including the patients who were infected with SARS CoV-2 virus confirmed by tests and those who never knew they had an infection early.People with long COVID may experience health problems from different types and combinations of symptoms over time,such as fa-tigue,dyspnea,cognitive impairments,and gastrointestinal(GI)symptoms(e.g.,nausea,vom-iting,diarrhea,decreased or loss of appetite,abdominal pain,and dysgeusia).The critical role of the microbiome in these GI symptoms and long COVID were reported in clinical patients and experimental models.Here,we provide an overall view of the critical role of the GI tract and microbiome in the development of long COVID,including the clinical GI symptoms in patients,dysbiosis,viral-microbiome interactions,barrier function,and inflammatory bowel disease patients with long COVID.We highlight the potential mechanisms and possible treatment based on GI health and microbiome.Finally,we discuss challenges and future direction in the long COVID clinic and research.

Gastrointestinal symptomsGI tractGut microbiomeInflammatory bowel diseasesIntestinal barrierLong COVIDMetabolitesTight junctions

Jilei Zhang、Yongguo Zhang、Yinglin Xia、Jun Sun

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Division of Gastroenterology and Hepatology,Department of Medicine,University of Illinois Chicago,IL 60612,USA

UIC Cancer Center,Department of Microbiology and Immunology,University of Illinois Chicago,Chicago,IL 60612,USA

Jesse Brown VA Medical Center,Chicago,IL 60612,USA

IllNET RECOVER pilotCrohn's & Colitis Foundation Senior Research AwardUnited States Department of Defense Congressionally Directed Medical Research ProgramsVA Merit Award

902766BC191198BX-19-00

2024

10.1016/j.gendis.2023.03.034

基因与疾病(英文)

基因与疾病(英文)

ISSN：
年,卷(期)：2024.11(3)
  • 131