首页|FGF21-mediated autophagy:Remodeling the homeostasis in response to stress in liver diseases

FGF21-mediated autophagy:Remodeling the homeostasis in response to stress in liver diseases

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Liver diseases are worldwide problems closely associated with various stresses,such as endoplasmic reticulum stress.The exact interplay between stress and liver diseases remains unclear.Autophagy plays an essential role in maintaining homeostasis,and recent studies indicate tight crosstalk between stress and autophagy in liver diseases.Once the bal-ance between damage and autophagy is broken,autophagy can no longer resist injury or main-tain homeostasis.In recent years,FGF21(fibroblast growth factor 21)-induced autophagy has attracted much attention.FGF21 is regarded as a stress hormone and can be up-regulated by an abundance of signaling pathways in response to stress.Also,increased FGF21 activates autophagy by a complicated signaling network in which mTOR plays a pivotal role.This review summarizes the mechanism of FGF21-mediated autophagy and its derived application in the defense of stress in liver diseases and offers a glimpse into its promising prospect in future clin-ical practice.

AutophagyFibroblast growth factor 21Liver diseasesmTORStress

Wei Shen、Modan Yang、Hao Chen、Chiyu He、Huigang Li、Xinyu Yang、Jianyong Zhuo、Zuyuan Lin、Zhihang Hu、Di Lu、Xiao Xu

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Zhejiang University School of Medicine,Hangzhou,Zhejiang 310058,China

Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province,Department of Hepatobiliary and Pancreatic Surgery,Affiliated Hangzhou First People's Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang 310006,China

The Institute for Organ Repair and Regenerative Medicine of Hangzhou,Hangzhou,Zhejiang 310006,China

Institute of Organ Transplantation,Zhejiang University,Hangzhou,Zhejiang 310003,China

National Center for Healthcare Quality Management in Liver Transplant,Hangzhou,Zhejiang 310003,China

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国家重点研发计划国家自然科学基金重大项目国家自然科学基金重点项目Young Program of National Natural Science Funds(China)Scientific Research Fund of Zhejiang Provincial Education Department(China)

2021YFA1100500921592028193001682000617Y202250784

2024

10.1016/j.gendis.2023.05.019

基因与疾病(英文)

基因与疾病(英文)

ISSN：
年,卷(期)：2024.11(3)
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