首页|Tumor microenvironment of cancer stem cells:Perspectives on cancer stem cell targeting
Tumor microenvironment of cancer stem cells:Perspectives on cancer stem cell targeting
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There are few tumor cell subpopulations with stem cell characteristics in tumor tis-sue,defined as cancer stem cells(CSCs)or cancer stem-like cells(CSLCs),which can recon-struct neoplasms with malignant biological behaviors such as invasiveness via self-renewal and unlimited generation.The microenvironment that CSCs depend on consists of various cellular components and corresponding medium components.Among these factors existing at a variety of levels and forms,cytokine networks and numerous signal pathways play an important role in signaling transduction.These factors promote or maintain cancer cell stem-ness,and participate in cancer recurrence,metastasis,and resistance.This review aims to summarize the recent molecular data concerning the multilayered relationship between CSCs and CSC-favorable microenvironments.We also discuss the therapeutic implications of target-ing this synergistic interplay,hoping to give an insight into targeting cancer cell stemness for tumor therapy and prognosis.
Cancer stem cellsCancer stem-like cellsCellular factorsNon-cellular factorsTumor microenvironment
Department of Pharmacy,The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital,Zhengzhou,Henan 450003,China
School of Life Science and Technology,Jiangsu Key Laboratory of Carcinogenesis and Intervention,China Pharmaceutical University,Nanjing,Jiangsu 211198,China
Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica,School of Pharmacy,Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210023,China
国家自然科学基金国家自然科学基金Medical Science and Technology Research Project of Henan Province,ChinaHenan Province Science and Technology Research ProjectPriority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions(China)
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