首页|Mitochondrial dysfunction:A promising therapeutic target for liver diseases
Mitochondrial dysfunction:A promising therapeutic target for liver diseases
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The liver is an important metabolic and detoxification organ and hence demands a large amount of energy,which is mainly produced by the mitochondria.Liver tissues of pa-tients with alcohol-related or non-alcohol-related liver diseases contain ultrastructural mito-chondrial lesions,mitochondrial DNA damage,disturbed mitochondrial dynamics,and compromised ATP production.Overproduction of mitochondrial reactive oxygen species in-duces oxidative damage to mitochondrial proteins and mitochondrial DNA,decreases mito-chondrial membrane potential,triggers hepatocyte inflammation,and promotes programmed cell death,all of which impair liver function.Mitochondrial DNA may be a poten-tial novel non-invasive biomarker of the risk of progression to liver cirrhosis and hepatocellular carcinoma in patients infected with the hepatitis B virus.We herein present a review of the mechanisms of mitochondrial dysfunction in the development of acute liver injury and chronic liver diseases,such as hepatocellular carcinoma,viral hepatitis,drug-induced liver injury,alcoholic liver disease,and non-alcoholic fatty liver disease.This review also discusses mito-chondrion-centric therapies for treating liver diseases.
Ping Chen、Lichao Yao、Mengqin Yuan、Zheng Wang、Qiuling Zhang、Yingan Jiang、Lanjuan Li
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Department of Infectious Diseases,Renmin Hospital of Wuhan University,Wuhan,Hubei 430060,China
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,National Clinical Research Center for Infectious Diseases,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,The First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou,Zhejiang 310003,China
Antiaging Research Center of Wuhan University Education Development Foundation,Hubei,ChinaNational Stem Cell Clinical Research Project of China(China Medical Biotechnology Association 2019)
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