The key mediator of diabetic kidney disease:Potassium channel dysfunction

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外文摘要：Diabetic kidney disease is a leading cause of end-stage renal disease,making it a global public health concern.The molecular mechanisms underlying diabetic kidney disease have not been elucidated due to its complex pathogenesis.Thus,exploring these mechanisms from new perspectives is the current focus of research concerning diabetic kidney disease.Ion channels are important proteins that maintain the physiological functions of cells and organs.Among ion channels,potassium channels stand out,because they are the most common and important channels on eukaryotic cell surfaces and function as the basis for cell excitability.Certain potassium channel abnormalities have been found to be closely related to diabetic kid-ney disease progression and genetic susceptibility,such as KATP,Kca,Kir,and Kv.In this review,we summarized the roles of different types of potassium channels in the occurrence and devel-opment of diabetic kidney disease to discuss whether the development of DKD is due to potas-sium channel dysfunction and present new ideas for the treatment of DKD.

外文关键词：

Channel dysfunctionDiabetic kidney diseaseEnd-stage renal diseaseIon channelPotassium

作者：

Jia Guo、Chaojie Zhang、Hui Zhao、Yufan Yan、Zhangsuo Liu

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作者单位：

Nephrology Research Center,The First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan 450052,China

Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province,Zhengzhou,Henan 450052,China

Research Center for Kidney Disease,Zhengzhou,Henan 450052,China

基金：

国家自然科学基金Science and Technology Research Project of Henan Province,ChinaScience and Technology Research Project of Henan Province,ChinaInnovation Scientists and Technicians Troop Construction Projects of Henan Province,China

项目编号：

82070745202102310051182102310571182101510002

出版年：

2024

DOI：

10.1016/j.gendis.2023.101119

基因与疾病(英文)

ISSN：

年,卷(期)：2024.11(4)