Recent advancement of sonogenetics:A promising noninvasive cellular manipulation by ultrasound

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外文摘要：Recent advancements in biomedical research have underscored the importance of noninvasive cellular manipulation techniques.Sonogenetics,a method that uses genetic engi-neering to produce ultrasound-sensitive proteins in target cells,is gaining prominence along with optogenetics,electrogenetics,and magnetogenetics.Upon stimulation with ultrasound,these proteins trigger a cascade of cellular activities and functions.Unlike traditional ultra-sound modalities,sonogenetics offers enhanced spatial selectivity,improving precision and safety in disease treatment.This technology broadens the scope of non-surgical interventions across a wide range of clinical research and therapeutic applications,including neuromodula-tion,oncologic treatments,stem cell therapy,and beyond.Although current literature pre-dominantly emphasizes ultrasonic neuromodulation,this review offers a comprehensive exploration of sonogenetics.We discuss ultrasound properties,the specific ultrasound-sensi-tive proteins employed in sonogenetics,and the technique's potential in managing conditions such as neurological disorders,cancer,and ophthalmic diseases,and in stem cell therapies.Our objective is to stimulate fresh perspectives for further research in this promising field.

外文关键词：

Mechanosensitive channelNeuromodulationSonogeneticsUltrasoundUltrasound-sensitive protein

作者：

Jin Tang、Mingxuan Feng、Dong Wang、Liang Zhang、Ke Yang

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作者单位：

Pediatric Research Institute,Children's Hospital of Chongqing Medical University,National Clinical Research Center for Child Health and Disorders,Ministry of Education Key Laboratory of Child Development and Disorders,China International Science and Technology Cooperation Base of Child Development and Critical Disorders,Chongqing Engineering Research Center of Stem Cell Therapy,Chongqing 400014,China

Department of Ultrasound,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,Chin

Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430074,China

Department of Ultrasound,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China

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基金：

National Natural Science Foundation of ChinaChongqing Science and Technology Committee,Chongqing,China

项目编号：

81771845CSTB2022NSCQ-MSX0812

出版年：

2024

DOI：

10.1016/j.gendis.2023.101112

基因与疾病(英文)

ISSN：

年,卷(期)：2024.11(5)