首页|LncRNAs are involved in regulating ageing and age-related disease through the adenosi ne monophosphate-activated protein kinase signalling pathway
LncRNAs are involved in regulating ageing and age-related disease through the adenosi ne monophosphate-activated protein kinase signalling pathway
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
万方数据
A long noncoding RNA(lncRNA)is longer than 200 bp.It regulates various biological processes mainly by interacting with DNA,RNA,or protein in multiple kinds of biological pro-cesses.Adenosine monophosphate-activated protein kinase(AMPK)is activated during nutrient starvation,especially glucose starvation and oxygen deficiency(hypoxia),and exposure to toxins that inhibit mitochondrial respiratory chain complex function.AMPK is an energy switch in organisms that controls cell growth and multiple cellular processes,including lipid and glucose metabolism,thereby maintaining intracellular energy homeostasis by activating catab-olism and inhibiting anabolism.The AMPK signalling pathway consists of AMPK and its upstream and downstream targets.AMPK upstream targets include proteins such as the transforming growth factor β-activated kinase 1(TAK1),liver kinase B1(LKB1),and calcium/calmodulin-dependent protein kinase β(CaMKKβ),and its downstream targets include proteins such as the mechanistic/mammalian target of rapamycin(mTOR)complex 1(mTORC1),hepatocyte nuclear factor 4α(HNF4α),and silencing information regulatory 1(SIRT1).In general,proteins function relatively independently and cooperate.In this article,a review of the currently known lncRNAs involved in the AMPK signalling pathway is presented and insights into the reg-ulatory mechanisms involved in human ageing and age-related diseases are provided.
Jiamei Li、Feng Xiao、Siqi Wang、Xiaolan Fan、Zhi He、Taiming Yan、Jia Zhang、Mingyao Yang、Deying Yang
展开 >
College of Animal Science and Technology,Sichuan Agricultural University,Chengdu,Sichuan 611130,China
Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province,Sichuan Agricultural University,Chengdu,Sichuan 611130,China
Chengdu Women's and Children's Central Hospital,School of Medicine,University of Electronic Science and Technology of China,Chengdu,Sichuan 610017,China
National Natural Science Foundation of ChinaChina Scholarship Council
万方数据
