首页|Protein lysine crotonylation in cellular processions and disease associations
Protein lysine crotonylation in cellular processions and disease associations
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Protein lysine crotonylation(Kcr)is one conserved form of posttranslational modi-fications of proteins,which plays an important role in a series of cellular physiological and pathological processes.Lysine ε-amino groups are the primary sites of such modification,re-sulting in four-carbon planar lysine crotonylation that is structurally and functionally distinct from the acetylation of these residues.High levels of Kcr modifications have been identified on both histone and non-histone proteins.The present review offers an update on the research progression regarding protein Kcr modifications in biomedical contexts and provides a discus-sion of the mechanisms whereby Kcr modification governs a range of biological processes.In addition,given the importance of protein Kcr modification in disease onset and progression,the potential viability of Kcr regulators as therapeutic targets is elucidated.
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