The landscape of epigenetic regulation and therapeutic application of N6-methyladenosine modifications in non-coding RNAs

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外文摘要：RNA N6-methyladenosine(m6A)methylation is the most abundant and conserved RNA modification in eukaryotes.It participates in the regulation of RNA metabolism and vanous pathophysiological processes.Non-coding RNAs(ncRNAs)are defined as small or long transcripts which do not encode proteins and display numerous biological regulatory functions.Similar to mRNAs,m6A deposition is observed in ncRNAs.Studying RNA m6A modifications on ncRNAs is of great importance specifically to deepen our understanding of their biological roles and clinical implications.In this review,we summarized the recent research findings regarding the mutual regulation between RNA m6A modification and ncRNAs(with a specific focus on mi-croRNAs,long non-coding RNAs,and circular RNAs)and their functions.We also discussed the challenges of m6A-containing ncRNAs and RNA m6A as therapeutic targets in human diseases and their future perspective in translational roles.

外文关键词：

Circular RNAEpigenetic regulationLong non-coding RNAMicroRNANon-coding RNARNA m6A modification

作者：

Gui-e Xu、Xuan Zhao、Guoping Li、Priyanka Gokulnath、Lijun Wang、Junjie Xiao

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作者单位：

Institute of Geriatrics(Shanghai University),Affiliated Nantong Hospital of Shanghai University(The Sixth People's Hospital of Nantong)and School of Life Sciences,Shanghai University,Nantong,Jiangsu 226011,China

Cardiac Regeneration and Ageing Lab,Institute of Cardiovascular Sciences,Shanghai Engineering Research Center of Organ Repair,School of Life Science,Shanghai University,Shanghai 200444,China

Cardiovascular Division of the Massachusetts General Hospital and Harvard Medical School,Boston,MA 02114,USA

基金：

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaScience and Technology Commission of Shanghai,ChinaScience and Technology Commission of Shanghai,ChinaScience and Technology Commission of Shanghai,ChinaNatural Science Foundation of Shanghai,China

项目编号：

8202010800282225005822702912341075010020DZ225540021XD142130023ZR1423000

出版年：

2024

DOI：

10.1016/j.gendis.2023.06.015

基因与疾病(英文)

ISSN：

年,卷(期)：2024.11(5)

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