M6A modification in cardiovascular disease:With a focus on programmed cell death

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外文摘要：N6-methyladenosine(m6A)methylation is one of the most predominant internal RNA modifications in eukaryotes and has become a hot spot in the field of epigenetics in recent years.Cardiovascular diseases(CVDs)are a leading cause of death globally.Emerging evidence demonstrates that RNA modifications,such as the m6A modification,are associated with the development and progression of many diseases,including CVDs.An increasing body of studies has indicated that programmed cell death(PCD)plays a vital role in CVDs.However,the mo-lecular mechanisms underlying m6A modification and PCD in CVDs remain poorly understood.Herein,elaborating on the highly complex connections between the m6A mechanisms and different PCD signaling pathways and clarifying the exact molecular mechanism of m6A modi-fication mediating PCD have significant meaning in developing new strategies for the preven-tion and therapy of CVDs.There is great potential for clinical application.

外文关键词：

ApoptosisAutophagyCardiovascular diseasesFerroptosisN6-methyladenosineProgrammed cell deathPyroptosis

作者：

Wen Li、Yao Liu、Ruiyan Xu、Yuan Zong、Lu He、Jun Hu、Guohua Li

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作者单位：

Institute of Cardiovascular Disease,Key Laboratory for Arteriosclerology of Hunan Province,Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease,Department of Pathophysiology,MOE Key Lab of Rare Pediatric Diseases,Hengyang Medical School,University of South China,Hengyang,Hunan 421001,China

Department of Cardiovascular Medicine,The Second Affiliated Hospital,Hengyang Medical School,University of South China,Hengyang,Hunan 421001,China

Department of Obstetrics and Gynecology,The First Affiliated Hospital,Hengyang Medical School,University of South China,Hengyang,Hunan 421001,China

Department of Cardiovascular Surgery,The Second Affiliated Hospital,Hengyang Medical School,University of South China,Hengyang,Hunan 421001,China

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基金：

Hunan Provincial Natural Science Foundation of ChinaHunan Provincial Natural Science Foundation of ChinaScientific Research Project of the Hunan Provincial Department of Education(China)Health Research Project of the Hunan Provincial Health Commission(China)

项目编号：

2022JJ305022022JJ3052720B493C202304027603

出版年：

2024

DOI：

10.1016/j.gendis.2023.05.023

基因与疾病(英文)

ISSN：

年,卷(期)：2024.11(5)