首页|Epigenetics:Mechanisms,potential roles,and therapeutic strategies in cancer progression
Epigenetics:Mechanisms,potential roles,and therapeutic strategies in cancer progression
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Mutations or abnormal expression of oncogenes and tumor suppressor genes are known to cause cancer.Recent studies have shown that epigenetic modifications are key drivers of cancer development and progression.Nevertheless,the mechanistic role of epige-netic dysregulation in the tumor microenvironment is not fully understood.Here,we reviewed the role of epigenetic modifications of cancer cells and non-cancer cells in the tumor micro-environment and recent research advances in cancer epigenetic drugs.In addition,we dis-cussed the great potential of epigenetic combination therapies in the clinical treatment of cancer.However,there are still some challenges in the field of cancer epigenetics,such as epigenetic tumor heterogeneity,epigenetic drug heterogeneity,and crosstalk between epige-netics,proteomics,metabolomics,and other omics,which may be the focus and difficulty of cancer treatment in the future.In conclusion,epigenetic modifications in the tumor microen-vironment are essential for future epigenetic drug development and the comprehensive treat-ment of cancer.Epigenetic combination therapy may be a novel strategy for the future clinical treatment of cancer.
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