Post-transcriptional regulation of DEAD-box RNA helicases in hematopoietic malignancies

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外文摘要：Hematopoiesis represents a meticulously regulated and dynamic biological process.Genetic aberrations affecting blood cells,induced by various factors,frequently give rise to hematological tumors.These instances are often accompanied by a multitude of abnormal post-transcriptional regulatory events,including RNA alternative splicing,RNA localization,RNA degradation,and storage.Notably,post-transcriptional regulation plays a pivotal role in preserving hematopoietic homeostasis.The DEAD-Box RNA helicase genes emerge as crucial post-transcriptional regulatory factors,intricately involved in sustaining normal hematopoiesis through diverse mechanisms such as RNA alternative splicing,RNA modification,and ribosome assembly.This review consolidates the existing knowledge on the role of DEAD-box RNA heli-cases in regulating normal hematopoiesis and underscores the pathogenicity of mutant DEAD-Box RNA helicases in malignant hematopoiesis.Emphasis is placed on elucidating both the pos-itive and negative contributions of DEAD-box RNA helicases within the hematopoietic system.

外文关键词：

DEAD-box RNA helicaseHemopoietic systemPost-transcriptional regulationRibosomes assemblyRNA alternative splicing

作者：

Jiankun Fan、Zhigang Li、Li Pei、Yu Hou

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作者单位：

Institute of Life Sciences,Chongqing Medical University,Chongqing 400016,China

Department of Hematology,Southwest Hospital,Third Military Medical University(Army Medical University),Chongqing 400038,China

基金：

Chongqing Science Fund for Distinguished Young ScholarsChongqing University Innovation Research Group ProjectChongqing Medical University Youth Innovation in Future MedicineNational Natural Science Foundation of ChinaNatural Science Foundation of Chongqing,China

项目编号：

CSTB2022NSCQ-JQX0032CXQT21011W015682200123CSTB2023NSCQ-MSX0280

出版年：

2024

DOI：

10.1016/j.gendis.2024.101252

基因与疾病(英文)

ISSN：

年,卷(期)：2024.11(5)

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