首页|PDCD2 as a prognostic biomarker in glioma correlates with malignant phenotype

PDCD2 as a prognostic biomarker in glioma correlates with malignant phenotype

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Programmed cell death 2(PDCD2)is related to cancer progression and chemo-therapy sensitivity.The role of PDCD2 in solid cancers(excluding hematopoietic malignancies)and their diagnosis and prognosis remains unclear.The TCGA,CGGA,GEPIA,cBioPortal,and GTEx databases were analyzed for expression,prognostic value,and genetic modifications of PDCD2 in cancer patients.Functional enrichment analysis,CCK8,colony formation assay,transwell assay,and xenograft tumor model were undertaken to study the PDCD2's biological function in glioma(GBMLGG).The PDCD2 gene was associated with solid cancer progression.In the functional enrichment analysis results,PDCD2 was shown to participate in several impor-tant GBMLGG biological processes.GBMLGG cells may be inhibited in their proliferation,migra-tion,invasion,and xenograft tumor growth by knocking down PDCD2.Our research can provide new insights into solid cancer prognostic biomarkers of PDCD2.

BiomarkerGliomaProgrammed cell death 2ProgressionSolid cancer

Fengsheng Dai、Yixiao Yuan、Jiaqi Hao、Xing Cheng、Xiangyi Zhou、Li Zhou、Rui Tian、Yi Zhao、Tingxiu Xiang

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Department of Oncology,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China

Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment,Chongqing University Cancer Hospital,Chongqing 400030,China

Department of Neurosurgery,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China

Hunan International Scientific and Technological Cooperation Base of Brain Tumor Research,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China

Department of Neuro-Oncology,Chongqing University Cancer Hospital,Chongqing 400030,China

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National Natural Science Foundation of ChinaNatural Science Foundation of Chongqing,ChinaFundamental Research Funds for the Central Universities in China

82172619CSTC2021jscxgksb-N00232022CDJYGRH-002

2024

10.1016/j.gendis.2023.101106

基因与疾病(英文)

基因与疾病(英文)

ISSN：
年,卷(期)：2024.11(5)
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