首页|N6-methyl-adenosine (m6A) in RNA: An Old Modification with A Novel Epigenetic Function

N6-methyl-adenosine (m6A) in RNA: An Old Modification with A Novel Epigenetic Function

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
  • 维普
N6-methyl-adenosine (m6A) is one of the most common and abundant modifications on RNA molecules present in eukaryotes.However,the biological significance of m6A methylation remains largely unknown.Several independent lines of evidence suggest that the dynamic regulation ofm6A may have a profound impact on gene expression regulation.The m6A modification is catalyzed by an unidentified methyltransferase complex containing at least one subunit methyltransferase like 3 (METTL3).m6A modification on messenger RNAs (mRNAs) mainly occurs in the exonic regions and 3′-untranslated region (3'-UTR) as revealed by high-throughput m6A-seq.One significant advance in m6A research is the recent discovery of the first two m6A RNA demethylases fat mass and obesity-associated (FTO) gene and ALKBH5,which catalyze m6A demethylation in an α-ketoglutarate (α-KG)-and Fe2+-dependent manner.Recent studies in model organisms demonstrate that METTL3,FTO and ALKBH5 play important roles in many biological processes,ranging from development and metabolism to fertility.Moreover,perturbation of activities of these enzymes leads to the disturbed expression of thousands of genes at the cellular level,implicating a regulatory role of m6A in RNA metabolism.Given the vital roles of DNA and histone methylations in epigenetic regulation of basic life processes in mammals,the dynamic and reversible chemical m6A modification on RNA may also serve as a novel epigenetic marker of profound biological significances.

N6-methyl-adenosineMETTL3FTOALKBH5RNA metabolism

Yamei Niu、Xu Zhao、Yong-Sheng Wu、Ming-Ming Li、Xiu-Jie Wang、Yun-Gui Yang

展开 >

Disease Genomics and Individualized Medicine Laboratory, Beijing Institute of Genomics, Chinese Academy of Sciences,Beijing 100101, China

University of Chinese Academy of Sciences, Beijing 100049, China

Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China

This study was supported by the China 973 programsThis study was supported by the China 973 programsCAS Innovation Program for Young Scientists to YNCAS "100-talents" Professor Program to YGY and the National Natural Science Foundation of ChinaCAS "100-talents" Professor Program to YGY and the National Natural Science Foundation of China

2011CB5101032012CB5183023090072481071648

2013

基因组蛋白质组与生物信息学报(英文版)
中国科学院北京基因组研究所

基因组蛋白质组与生物信息学报(英文版)

CSCD
影响因子：0.495
ISSN：1672-0229
年,卷(期)：2013.11(1)
  • 32
  • 103