首页|Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA
Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA
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Advances in genomics technology over recent years have led to the surprising discovery that the genome is far more pervasively transcribed than was previously appreciated. Much of the newly-discovered transcriptome appears to represent long non-coding RNA (lncRNA), a heteroge-neous group of largely uncharacterised transcripts. Understanding the biological function of these molecules represents a major challenge and in this review we discuss some of the progress made to date. One major theme of lncRNA biology seems to be the existence of a network of interactions with microRNA (miRNA) pathways. lncRNA has been shown to act as both a source and an inhi-bitory regulator of miRNA. At the transcriptional level, a model is emerging whereby lncRNA bridges DNA and protein by binding to chromatin and serving as a scaffold for modifying protein complexes. Such a mechanism can bridge promoters to enhancers or enhancer-like non-coding genes by regulating chromatin looping, as well as conferring specificity on histone modifying com-plexes by directing them to specific loci.
Long non-coding RNAMicroRNATranscriptional regulationEpigeneticsPost-transcriptional regulation
Iain M. Dykes、Costanza Emanueli
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School of Clinical Sciences, University of Bristol, Bristol BS28HW, United Kingdom
National Heart and Lung Institute, Imperial College London, London SW72AZ, United Kingdom
Funding was provided by the British Heart Foundation, UK
NETL
NSTL
万方数据
维普
