首页|Integration of Computational Analysis and Spatial Transcriptomics in Single-cell Studies

Integration of Computational Analysis and Spatial Transcriptomics in Single-cell Studies

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Recent advances of single-cell transcriptomics technologies and allied computational methodologies have revolutionized molecular cell biology.Meanwhile,pioneering explorations in spatial transcriptomics have opened up avenues to address fundamental biological questions in health and diseases.Here,we review the technical attributes of single-cell RNA sequencing and spa-tial transcriptomics,and the core concepts of computational data analysis.We further highlight the challenges in the application of data integration methodologies and the interpretation of the biolog-ical context of the findings.

scRNA-seqComputational methodologySpatial transcriptomeData integrationMathematical model

Ran Wang、Guangdun Peng、Patrick P.L.Tam、Naihe Jing

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State Key Laboratory of Cell Biology,CAS Center for Excellence in Molecular Cell Science,Shanghai Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,University of Chinese Academy of Sciences,Shanghai 200031,China

CAS Key Laboratory of Regenerative Biology,Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine,Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences,Guangzhou 510530,China

Institute for Stem Cell and Regeneration,Chinese Academy of Sciences,Beijing 100101,China

Embryology Research Unit,Children's Medical Research Institute,University of Sydney,Sydney,NSW 2145,Australia

School of Medical Sciences,Faculty of Medicine and Health,University of Sydney,Sydney,NSW 2145,Australia

Institute for Stem Cell and Regeneration,Chinese Academy of Sci

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National Key Basic Research and Development Program of ChinaNational Key Basic Research and Development Program of ChinaNational Key Basic Research and Development Program of ChinaNational Key Basic Research and Development Program of ChinaNational Key Basic Research and Development Program of ChinaNational Key Basic Research and Development Program of Chinathe"Strategic Priority Research Program"of the Chinese Academy of Sciencesthe"Strategic Priority Research Program"of the Chinese Academy of SciencesNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaChina Postdoctoral Science Foundation Grant

2019YFA08014022018YFA01072002018YFA08014022018YFA08001002018YFA01080002017YFA0102700XDA16020501XDA1602040431630043319005732018M642106

2023

10.1016/j.gpb.2022.06.006

基因组蛋白质组与生物信息学报(英文版)
中国科学院北京基因组研究所

基因组蛋白质组与生物信息学报(英文版)

CSTPCDCSCD
影响因子：0.495
ISSN：1672-0229
年,卷(期)：2023.21(1)
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