首页|Gut Microbiome in Colorectal Cancer:Clinical Diagnosis and Treatment

Gut Microbiome in Colorectal Cancer:Clinical Diagnosis and Treatment

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Colorectal cancer(CRC)is one of the most frequently diagnosed cancers and the leading cause of cancer-associated deaths.Epidemiological studies have shown that both genetic and envi-ronmental risk factors contribute to the development of CRC.Several metagenomic studies of CRC have identified gut dysbiosis as a fundamental risk factor in the evolution of colorectal malignancy.Although enormous efforts and substantial progresses have been made in understanding the rela-tionship between human gut microbiome and CRC,the precise mechanisms involved remain elusive.Recent data have shown a direct causative role of the gut microbiome in DNA damage,inflamma-tion,and drug resistance in CRC,suggesting that modulation of gut microbiome could act as a powerful tool in CRC prevention and therapy.Here,we provide an overview of the relationship between gut microbiome and CRC,and explore relevant mechanisms of colorectal tumorigenesis.We next highlight the potential of bacterial species as clinical biomarkers,as well as their roles in therapeutic response.Factors limiting the clinical translation of gut microbiome and strategies for resolving current challenges are further discussed.

Gut microbiomeColorectal cancerDiagnostic biomarkerImmunotherapyChemotherapy

Yali Liu、Harry Cheuk-Hay Lau、Wing Yin Cheng、Jun Yu

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Institute of Digestive Disease and The Department of Medicine and Therapeutics,State Key Laboratory of Digestive Disease,Li Ka Shing Institute of Health Sciences,CUHK Shenzhen Research Institute,The Chinese University of Hong Kong,Hong Kong Special Administrative Region 999077,China

Research Grants Council(RGC)Themebased Res Scheme Hong KongRGC Collaborative Research FundRGC Collaborative Research FundRGC-General Research Fund(GRF)Hong KongVice-Chancellor's Discretionary Fund Chinese University of Hong Kong,China

T21-705/20-NC4039-19GFC7065-18GF14163817

2023

10.1016/i.gpb.2022.07.002

基因组蛋白质组与生物信息学报(英文版)
中国科学院北京基因组研究所

基因组蛋白质组与生物信息学报(英文版)

CSTPCDCSCD
影响因子：0.495
ISSN：1672-0229
年,卷(期)：2023.21(1)
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