The First High-quality Reference Genome of Sika Deer Provides Insights into High-tannin Adaptation

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外文摘要：Sika deer are known to prefer oak leaves,which are rich in tannins and toxic to most mammals;however,the genetic mechanisms underlying their unique ability to adapt to living in the jungle are still unclear.In identifying the mechanism responsible for the tolerance of a highly toxic diet,we have made a major advancement by explaining the genome of sika deer.We generated the first high-quality,chromosome-level genome assembly of sika deer and measured the correlation between tannin intake and RNA expression in 15 tissues through 180 experiments.Comparative genome analyses showed that the UGT and CYP gene families are functionally involved in the adaptation of sika deer to high-tannin food,especially the expansion of the UGT family 2 subfamily B of UGT genes.The first chromosome-level assembly and genetic characterization of the tolerance to a highly toxic diet suggest that the sika deer genome may serve as an essential resource for under-standing evolutionary events and tannin adaptation.Our study provides a paradigm of comparative expressive genomics that can be applied to the study of unique biological features in non-model ani-mals.

外文关键词：

Sika deerWhole-genome sequencingChromosome-scale assem-blyOak leafTannin tolerance

作者：

Xiumei Xing、Cheng Ai、Tianjiao Wang、Yang Li、Huitao Liu、Pengfei Hu、Guiwu Wang、Huamiao Liu、Hongliang Wang、Ranran Zhang、Junjun Zheng、Xiaobo Wang、Lei Wang、Yuxiao Chang、Qian Qian、Jinghua Yu、Lixin Tang、Shigang Wu、Xiujuan Shao、Alun Li、Peng Cui、Wei Zhan、Sheng Zhao、Zhichao Wu、Xiqun Shao、Yimeng Dong、Min Rong、Yihong Tan、Xuezhe Cui、Shuzhuo Chang、Xingchao Song、Tongao Yang、Limin Sun、Yan Ju、Pei Zhao、Huanhuan Fan、Ying Liu、Xinhui Wang、Wanyun Yang、Min Yang、Tao Wei、Shanshan Song、Jiaping Xu、Zhigang Yue、Qiqi Liang、Chunyi Li、Jue Ruan、Fuhe Yang

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作者单位：

Key Laboratory of Genetics,Breeding and Reproduction of Special Economic Animals,Ministry of Agriculture and Rural Affairs,Institute of Special Animal and Plant Sciences,Chinese Academy of Agricultural Sciences,Changchun 130112,China

Shenzhen Branch,Guangdong Laboratory of Lingnan Modern Agriculture,Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs,Agricultural Genomics Institute at Shenzhen,Chinese Academy of Agricultural Sciences,Shenzhen 518120,China

CAS Key Laboratory of Forest Ecology and Management,Institute of Applied Ecology,Chinese Academy of Sciences,Shenyang 110016,China

Annoroad Gene Technology(Beijing)Co.,Ltd,Beijing 100176,China

Novogene Bioinformatics Institute,Beijing 100083,China

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基金：

National Key R&D Program of ChinaAgricultural Science and Technology Innovation Program of ChinaSpecial Animal Genetic Resources Platform of National Scientific and Technical Infrastructure CenterSika deer Genome Project of China

项目编号：

2018YFD0502204CAAS-ASTIP-2019-ISAPSNSTIC TZDWZYK201920140309016YY

出版年：

2023

DOI：

10.1016/j.gpb.2022.05.008

基因组蛋白质组与生物信息学报(英文版)

中国科学院北京基因组研究所

基因组蛋白质组与生物信息学报(英文版)

CSTPCDCSCD

影响因子：0.495

ISSN：1672-0229

年,卷(期)：2023.21(1)

参考文献量51