OOCDB:A Comprehensive,Systematic,and Real-time Organs-on-a-chip Database

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外文摘要：Organs-on-a-chip is a microfluidic microphysiological system that uses microfluidic tech-nology to analyze the structure and function of living human cells at the tissue and organ levels in vitro.Organs-on-a-chip technology,as opposed to traditional two-dimensional cell culture and animal models,can more closely simulate pathologic and toxicologic interactions between different organs or tissues and reflect the collaborative response of multiple organs to drugs.Despite the fact that many organs-on-a-chip-related data have been published,none of the current databases have all of the following functions:searching,downloading,as well as analyzing data and results from the literature on organs-on-a-chip.Therefore,we created an organs-on-a-chip database(OOCDB)as a platform to integrate information about organs-on-a-chip from various sources,including lit-erature,patents,raw data from microarray and transcriptome sequencing,several open-access datasets of organs-on-a-chip and organoids,and data generated in our laboratory.OOCDB con-tains dozens of sub-databases and analysis tools,and each sub-database contains various data associated with organs-on-a-chip,with the goal of providing researchers with a comprehensive,sys-tematic,and convenient search engine.Furthermore,it offers a variety of other functions,such as mathematical modeling,three-dimensional modeling,and citation mapping,to meet the needs of researchers and promote the development of organs-on-a-chip.The OOCDB is available at http://www.organchip.cn.

外文关键词：

DatabaseOrganMathematical modelCitation mapOrgans-on-a-chip

作者：

Jian Li、Weicheng Liang、Zaozao Chen、Xingyu Li、Pan Gu、Anna Liu、Pin Chen、Qiwei Li、Xueyin Mei、Jing Yang、Jun Liu、Lincao Jiang、Zhongze Gu

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作者单位：

School of Life Science and Technology,Southeast University,Nanjing 210096,China

School of Biological Science & Medical Engineering,Southeast University,Nanjing 210096,China

School of Computer,Data & Information Sciences,University of Wisconsin-Madison,Madison,WI53706,USA

基金：

This study is mainly supported by the National Natural Science Foundation of ChinaNational Key R&D Program of ChinaFundamental Research Funds for the Central Universities,ChinaFundamental Research Funds for the Central Universities,China

项目编号：

318713222017YFA07005002242020 k100012242019 k10016

出版年：

2023

DOI：

10.1016/j.gpb.2023.01.001

基因组蛋白质组与生物信息学报(英文版)

中国科学院北京基因组研究所

基因组蛋白质组与生物信息学报(英文版)

CSTPCDCSCD

影响因子：0.495

ISSN：1672-0229

年,卷(期)：2023.21(2)

参考文献量30