首页|VIS Atlas:A Database of Virus Integration Sites in Human Genome from NGS Data to Explore Integration Patterns

VIS Atlas:A Database of Virus Integration Sites in Human Genome from NGS Data to Explore Integration Patterns

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Integration of oncogenic DNA viruses into the human genome is a key step in most virus-induced carcinogenesis.Here,we constructed a virus integration site(VIS)Atlas database,an exten-sive collection of integration breakpoints for three most prevalent oncoviruses,human papillo-mavirus,hepatitis B virus,and Epstein-Barr virus based on the next-generation sequencing(NGS)data,literature,and experimental data.There are 63,179 breakpoints and 47,411 junctional sequences with full annotations deposited in the VIS Atlas database,comprising 47 virus genotypes and 17 disease types.The VIS Atlas database provides(1)a genome browser for NGS breakpoint quality check,visualization of VISs,and the local genomic context;(2)a novel platform to discover integration patterns;and(3)a statistics interface for a comprehensive investigation of genotype-specific integration features.Data collected in the VIS Atlas aid to provide insights into virus patho-genic mechanisms and the development of novel antitumor drugs.The VIS Atlas database is avail-able at https://www.vis-atlas.tech/.

DNA virusVirus integration siteNext-generation sequencingIntegration patternVirus genotype

Ye Chen、Yuyan Wang、Ping Zhou、Hao Huang、Rui Li、Zhen Zeng、Zifeng Cui、Rui Tian、Zhuang Jin、Jiashuo Liu、Zhaoyue Huang、Lifang Li、Zheying Huang、Xun Tian、Meiying Yu、Zheng Hu

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Department of Obstetrics and Gynecology,the First Affiliated Hospital,Sun Yat-sen University,Guangzhou 510000,China

Department of Obstetrics and Gynecology,Dongguan Maternal and Child Health Care Hospital,Dongguan 523000,China

Office of Scientific Research & Development,Sun Yat-sen University,Guangzhou 510000,China

Department of Obstetrics and Gynecology,Academician Expert Workstation,The Central Hospital of Wuhan,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430000,China

Center for Translational Medicine,the First Affiliated Hospital,Sun Yat-sen University,Guangzhou 510000,China

Department of Pathology,the Central Hospital of Enshi Tujia and Miao Autonomous Prefecture,Enshi 445000,China

Department of Obstetrics and Gynecology,Zhongnan Hospital of Wuhan University,Wuhan 430062,China

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National Science and Technology Major Project of the Ministry of Science and Technology of ChinaNational Natural Science Foundation of ChinaMajor Projects of Guangzhou Science and Technology Bureau,ChinaNational Ten Thousands Plan for Young Top TalentsYoung Pearl River ScholarInternational Cooperation and Exchange Projects of the National Natural Science Foundation of China(China & Russian)Major Projects of Wuhan Municipal Health Commission of ChinaMajor Projects of Hubei Provincial Health Commission of ChinaDongguan Social Development Key Project of ChinaRegional Joint Fund Project of Guangdong Basic and Applied Basic Research Foundation of China(Regional Cultivation Project)Dongguan Social Development Key Project of China

2018ZX103014028176114802520170402009317-54-80078WX19M02WJ2019H3122020507150072212021B151514006320221800905772

2023

10.1016/j.gpb.2023.02.005

基因组蛋白质组与生物信息学报(英文版)
中国科学院北京基因组研究所

基因组蛋白质组与生物信息学报(英文版)

CSTPCDCSCD
影响因子：0.495
ISSN：1672-0229
年,卷(期)：2023.21(2)
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