首页|TIGER:A Web Portal of Tumor Immunotherapy Gene Expression Resource

TIGER:A Web Portal of Tumor Immunotherapy Gene Expression Resource

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Immunotherapy is a promising cancer treatment method;however,only a few patients benefit from it.The development of new immunotherapy strategies and effective biomarkers of response and resistance is urgently needed.Recently,high-throughput bulk and single-cell gene expression profiling technologies have generated valuable resources.However,these resources are not well organized and systematic analysis is difficult.Here,we present TIGER,a tumor immunotherapy gene expression resource,which contains bulk transcriptome data of 1508 tumor samples with clinical immunotherapy outcomes and 11,057 tumor/normal samples without clinical immunotherapy outcomes,as well as single-cell transcrip tome data of 2,116,945 immune cells from 655 samples.TIGER provides many useful modules for analyzing collected and user-provided data.Using the resource in TIGER,we identified a tumor-enriched subset of CD4+T cells.Patients with melanoma with a higher signature score of this subset have a significantly better response and survival under immunotherapy.We believe that TIGER will be helpful in understanding anti-tumor immunity mechanisms and discovering effective biomarkers.TIGER is freely accessible at http://tiger.canceromics.org/.

ImmunotherapyBiomarkerGene expressionSingle-cell RNA-seqWeb server

Zhihang Chen、Ziwei Luo、Di Zhang、Huiqin Li、Xuefei Liu、Kaiyu Zhu、Hongwan Zhang、Zongping Wang、Penghui Zhou、Jian Ren、An Zhao、Zhixiang Zuo

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State Key Laboratory of Oncology in South China,Cancer Center,Collaborative Innovation Center for Cancer Medicine,School of Life Sciences,Sun Yat-sen University,Guangzhou 510060,China

Department of Gastrointestinal Surgery,Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases,Guangdong Institute of Gastroenterology,The Sixth Affiliated Hospital,Sun Yat-sen University,Guangzhou 510655,China

Department of Urology,Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital),Hangzhou 310016,China

Experimental Research Center,Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital),Hangzhou 310016,China

Institute of Cancer and Basic Medicine(IBMC),Chinese Academy of Sciences,Hangzhou 310000,China

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National Natural Science Foundation of ChinaNational Key R&D Program of ChinaProgram for Guangdong Introducing Innovative and Entrepreneurial TeamsZhejiang Qianjiang Talent ProjectGuangdong Basic and Applied Basic Research Foundation,China

817726142017YFA01067002017ZT07S096QJD16020252021 B1515020108

2023

10.1016/j.gpb.2022.08.004

基因组蛋白质组与生物信息学报(英文版)
中国科学院北京基因组研究所

基因组蛋白质组与生物信息学报(英文版)

CSTPCDCSCD
影响因子：0.495
ISSN：1672-0229
年,卷(期)：2023.21(2)
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