首页|Dynamic Spatial-temporal Expression Ratio of X Chromosome to Autosomes but Stable Dosage Compensation in Mammals

Dynamic Spatial-temporal Expression Ratio of X Chromosome to Autosomes but Stable Dosage Compensation in Mammals

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In the evolutionary model of dosage compensation,per-allele expression level of the X chromosome has been proposed to have twofold up-regulation to compensate its dose reduction in males(XY)compared to females(XX).However,the expression regulation of X-linked genes is still controversial,and comprehensive evaluations are still lacking.By integrating multi-omics datasets in mammals,we investigated the expression ratios including X to autosomes(X∶AA ratio)and X to orthologs(X∶XX ratio)at the transcriptome,translatome,and proteome levels.We revealed a dynamic spatial-temporal X∶AA ratio during development in humans and mice.Mean-while,by tracing the evolution of orthologous gene expression in chickens,platypuses,and opos-sums,we found a stable expression ratio of X-linked genes in humans to their autosomal orthologs in other species(X∶XX ≈ 1)across tissues and developmental stages,demonstrating stable dosage compensation in mammals.We also found that different epigenetic regulations con-tributed to the high tissue specificity and stage specificity of X-linked gene expression,thus affecting X∶AA ratios.It could be concluded that the dynamics of X∶AA ratios were attributed to the differ-ent gene contents and expression preferences of the X chromosome,rather than the stable dosage compensation.

Dosage compensationX chromosomeMammalEvolutionRNA-seq

Sheng Hu Qian、Yu-Li Xiong、Lu Chen、Ying-Jie Geng、Xiao-Man Tang、Zhen-Xia Chen

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Hubei Key Laboratory of Agricultural Bioinformatics,College of Life Science and Technology,Huazhong Agricultural University,Wuhan 430070,China

Hubei Hongshan Laboratory,College of Biomedicine and Health,Huazhong Agricultural University,Wuhan 430070,China

Interdisciplinary Sciences Institute,Huazhong Agricultural University,Wuhan 430070,China

National Natural Science Foundation of ChinaOpening Foundation of State Key Laboratory of Freshwater Ecology and Biotechnology,ChinaFundamental Research Funds for the Central Universities,ChinaFundamental Research Funds for the Central Universities,ChinaHuazhong Agricultural University Scientific & Technological Selfinnovation Foundation,China

318713052020FB082662018PY0212662019PY0032016RC011

2023

10.1016/j.gpb.2022.08.003

基因组蛋白质组与生物信息学报(英文版)
中国科学院北京基因组研究所

基因组蛋白质组与生物信息学报(英文版)

CSTPCDCSCD
影响因子：0.495
ISSN：1672-0229
年,卷(期)：2023.21(3)
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