首页|The Integrative Studies on the Functional A-to-I RNA Editing Events in Human Cancers

The Integrative Studies on the Functional A-to-I RNA Editing Events in Human Cancers

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Adenosine-to-inosine(A-to-I)RNA editing,constituting nearly 90％of all RNA editing events in humans,has been reported to contribute to the tumorigenesis in diverse cancers.However,the comprehensive map for functional A-to-I RNA editing events in cancers is still insufficient.To fill this gap,we systematically and intensively analyzed multiple tumorigenic mechanisms of A-to-I RNA editing events in samples across 33 cancer types from The Cancer Genome Atlas.For indi-vidual candidate among～1,500,000 quantified RNA editing events,we performed diverse types of downstream functional annotations.Finally,we identified 24,236 potentially functional A-to-I RNA editing events,including the cases in APOL1,IGFBP3,GRIA2,BLCAP,and miR-589-3p.These events might play crucial roles in the scenarios of tumorigenesis,due to their tumor-related editing frequencies or probable effects on altered expression profiles,protein func-tions,splicing patterns,and microRNA regulations of tumor genes.Our functional A-to-I RNA editing events(https://ccsm.uth.edu/CAeditome/)will help better understand the cancer pathology from the A-to-I RNA editing aspect.

A-to-I RNA editingCancerProtein recodingAlternative splicingMicroRNA regulation

Sijia Wu、Zhiwei Fan、Pora Kim、Liyu Huang、Xiaobo Zhou

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School of Life Science and Technology,Xidian University,Xi'an 710071,China

West China School of Public Health and West China Fourth Hospital,Sichuan University,Chengdu 610040,China

Center for Computational Systems Medicine,School of Biomedical Informatics,The University of Texas Health Science Center at Houston,Houston,TX 77030,USA

National Natural Science Foundation of ChinaFundamental Research Funds for the Central UniversitiesNatural Science Foundation of Shaanxi Province of ChinaChina Postdoctoral Science FoundationNational Natural Science Foundation of ChinaNational Key R&D Program of ChinaNational Natural Science Foundation of China

620022702020JQ-3322018M643583822278022017YFA020520261672422

2023

10.1016/j.gpb.2022.12.010

基因组蛋白质组与生物信息学报(英文版)
中国科学院北京基因组研究所

基因组蛋白质组与生物信息学报(英文版)

CSTPCDCSCD
影响因子：0.495
ISSN：1672-0229
年,卷(期)：2023.21(3)
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