首页|N6-methyladenosine and Its Implications in Viruses

N6-methyladenosine and Its Implications in Viruses

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N6-methyladenine(m6A)is the most abundant RNA modification in mammalian mes-senger RNAs(mRNAs),which participates in and regulates many important biological activities,such as tissue development and stem cell differentiation.Due to an improved understanding of m6A,researchers have discovered that the biological function of m6A can be linked to many stages of mRNA metabolism and that m6A can regulate a variety of complex biological processes.In addi-tion to its location on mammalian mRNAs,m6A has been identified on viral transcripts.m6A also plays important roles in the life cycle of many viruses and in viral replication in host cells.In this review,we briefly introduce the detection methods of m6A,the m6A-related proteins,and the func-tions of m6A.We also summarize the effects of m6A-related proteins on viral replication and infec-tion.We hope that this review provides researchers with some insights for elucidating the complex mechanisms of the epitranscriptome related to viruses,and provides information for further study of the mechanisms of other modified nucleobases acting on processes such as viral replication.We also anticipate that this review can stimulate collaborative research from different fields,such as chemistry,biology,and medicine,and promote the development of antiviral drugs and vaccines.

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Yafen Wang、Xiang Zhou

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College of Chemistry and Molecular Sciences,Wuhan University,Wuhan 430072,China

School of Public Health,Wuhan University,Wuhan 430071,China

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaPostdoctoral Innovative Talent Support Program of ChinaChina Postdoctoral Science Foundation

219070779175320121721005BX201802282019M652691

2023

10.1016/j.gpb.2022.04.009

基因组蛋白质组与生物信息学报(英文版)
中国科学院北京基因组研究所

基因组蛋白质组与生物信息学报(英文版)

CSTPCDCSCD
影响因子：0.495
ISSN：1672-0229
年,卷(期)：2023.21(4)
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