首页|Screening Linear and Circular RNA Transcripts from Stress Granules
Screening Linear and Circular RNA Transcripts from Stress Granules
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Stress granules(SGs)are cytoplasmic ribonucleoprotein assemblies formed under stress conditions and are related to various biological processes and human diseases.Previous studies have reported the regulatory role of some proteins and linear RNAs in SG assembly.However,the relationship between circular RNAs(circRNAs)and SGs has not been discovered.Here,we screened both linear RNAs and circRNAs in SGs using improved total RNA sequencing of purified SG cores in mammalian cells and identified circular transcripts specifically localized in SGs.circRNAs with higher SG-related RNA-binding protein(RBP)binding abilities are more likely to be enriched in SGs.Furthermore,some SG-enriched circRNAs are differentially expressed in hepatocellular carcinoma(HCC)and adjacent tissues.These results suggest the regulatory role of circRNAs in SG formation and provide insights into the biological function of circRNAs and SGs in HCC.
Beijing Institutes of Life Science,Chinese Academy of Sciences,Beijing 100101,China
University of Chinese Academy of Sciences,Beijing 100049,China
Center for Excellence in Animal Evolution and Genetics,Chinese Academy of Sciences,Kunming 650223,China
Key Laboratory of Systems Biology,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou 310013,China
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National Key R&D Program of ChinaNational Key R&D Program of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of China
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