首页|Omics Views of Mechanisms for Cell Fate Determination in Early Mammalian Development

Omics Views of Mechanisms for Cell Fate Determination in Early Mammalian Development

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During mammalian preimplantation development,a totipotent zygote undergoes several cell cleavages and two rounds of cell fate determination,ultimately forming a mature blastocyst.Along with compaction,the establishment of apicobasal cell polarity breaks the symmetry of an embryo and guides subsequent cell fate choice.Although the lineage segregation of the inner cell mass(ICM)and trophectoderm(TE)is the first symbol of cell differentiation,several molecules have been shown to bias the early cell fate through their inter-cellular variations at much earlier stages,including the 2-and 4-cell stages.The underlying mechanisms of early cell fate determination have long been an important research topic.In this review,we summarize the molecular events that occur during early embryogenesis,as well as the current understanding of their regulatory roles in cell fate decisions.Moreover,as powerful tools for early embryogenesis research,single-cell omics techniques have been applied to both mouse and human preimplantation embryos and have con-tributed to the discovery of cell fate regulators.Here,we summarize their applications in the research of preimplantation embryos,and provide new insights and perspectives on cell fate regu-lation.

Cell fate determinationCellular-heterogeneityCell polaritySingle-cell omicsMammalian preimplantation embryo

Lin-Fang Ju、Heng-Ji Xu、Yun-Gui Yang、Ying Yang

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Sino-Danish College,University of Chinese Academy of Sciences,Beijing 100049,China

University of Chinese Academy of Sciences,Beijing 100049,China

CAS Key Laboratory of Genomic and Precision Medicine,Collaborative Innovation Center of Genetics and Development,Beijing Institute of Genomics,Chinese Academy of Sciences and China National Center for Bioinformation,Beijing 100101,China

Institute of Stem Cell and Regeneration,Chinese Academy of Sciences,Beijing 100101,China

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National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaCAS for Young Scientists in Basic Research ProjectStrategic Priority Research Program of CASNational Key R&D Program of ChinaYouth Innovation Promotion Association of CASBeijing Nova Program,ChinaBeijing Nova Program,China

3212100192153303YSBR-073XDA160105012018YFA0801200Y2022040Z20110000682010420220484210

2023

10.1016/j.gpb.2023.03.001

基因组蛋白质组与生物信息学报(英文版)
中国科学院北京基因组研究所

基因组蛋白质组与生物信息学报(英文版)

CSTPCDCSCD
影响因子：0.495
ISSN：1672-0229
年,卷(期)：2023.21(5)
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