首页|Differential Transcriptomic Landscapes of SARS-CoV-2 Variants in Multiple Organs from Infected Rhesus Macaques

Differential Transcriptomic Landscapes of SARS-CoV-2 Variants in Multiple Organs from Infected Rhesus Macaques

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Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)caused the persistent coronavirus disease 2019(COVID-19)pandemic,which has resulted in millions of deaths world-wide and brought an enormous public health and global economic burden.The recurring global wave of infections has been exacerbated by growing variants of SARS-CoV-2.In this study,the virological characteristics of the original SARS-CoV-2 strain and its variants of concern(VOCs;including Alpha,Beta,and Delta)in vitro,as well as differential transcriptomic landscapes in mul-tiple organs(lung,right ventricle,blood,cerebral cortex,and cerebellum)from the infected rhesus macaques,were elucidated.The original strain of SARS-CoV-2 caused a stronger innate immune response in host cells,and its VOCs markedly increased the levels of subgenomic RNAs,such as N,Orf9b,Orf6,and Orf7ab,which are known as the innate immune antagonists and the inhibitors of antiviral factors.Intriguingly,the original SARS-CoV-2 strain and Alpha variant induced larger alteration of RNA abundance in tissues of rhesus monkeys than Beta and Delta variants did.More-over,a hyperinflammatory state and active immune response were shown in the right ventricles of rhesus monkeys by the up-regulation of inflammation-and immune-related RNAs.Furthermore,peripheral blood may mediate signaling transmission among tissues to coordinate the molecular changes in the infected individuals.Collectively,these data provide insights into the pathogenesis of COVID-19 at the early stage of infection by the original SARS-CoV-2 strain and its VOCs.

SARS-CoV-2Variant of concernSubgenomic RNARhesus macaqueTranscriptome

Tingfu Du、Chunchun Gao、Shuaiyao Lu、Qianlan Liu、Yun Yang、Wenhai Yu、Wenjie Li、Yong Qiao Sun、Cong Tang、Junbin Wang、Jiahong Gao、Yong Zhang、Fangyu Luo、Ying Yang、Yun-Gui Yang、Xiaozhong Peng

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National Kunming High-level Biosafety Primate Research Center,Institute of Medical Biology,Chinese Academy of Medical Sciences and Peking Union Medical College,Kunming 650118,China

State Key Laboratory of Medical Molecular Biology,Department of Molecular Biology and Biochemistry,Institute of Basic Medical Sciences,Medical Primate Research Center,Neuroscience Center,Chinese Academy of Medical Sciences,School of Basic Medicine,Peking Union Medical College,Beijing 100005,China

CAS Key Laboratory of Genomic and Precision Medicine,Collaborative Innovation Center of Genetics and Development,College of Future Technology,Beijing Institute of Genomics,Chinese Academy of Sciences and China National Center for Bioinformation,Beijing 100101,China

Sino-Danish College,University of Chinese Academy of Sciences,Beijing 100049,China

Institute of Stem Cell and Regeneration,Chinese Academy of Sciences,Beijing 100101,China

Institute of Laboratory Animal Sc

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National Key R&D Program of ChinaStrategic Priority Research Program of Chinese Academy of SciencesCAMS Innovation Fund for Medical SciencesSTI2030-Major ProjectsFoundation for Innovative Research Groups of the National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaK.C.Wong Education FoundationShanghai Municipal Science and Technology Major Project,ChinaChina National Postdoctoral Program for Innovative Talents

2021YFC0863300XDB04900002021-I2M-1-0242021ZD020090082221004321210013220046032200460GJTD-2019-082017SHZDZX01BX2021291

2023

10.1016/j.gpb.2023.06.002

基因组蛋白质组与生物信息学报(英文版)
中国科学院北京基因组研究所

基因组蛋白质组与生物信息学报(英文版)

CSTPCDCSCD
影响因子：0.495
ISSN：1672-0229
年,卷(期)：2023.21(5)
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