首页|The Proteome Landscape of Human Placentas for Monochorionic Twins with Selective Intrauterine Growth Restriction

The Proteome Landscape of Human Placentas for Monochorionic Twins with Selective Intrauterine Growth Restriction

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In perinatal medicine,intrauterine growth restriction(IUGR)is one of the greatest chal-lenges.The etiology of IUGR is multifactorial,but most cases are thought to arise from placental insufficiency.However,identifying the placental cause of IUGR can be difficult due to numerous confounding factors.Selective IUGR(sIUGR)would be a good model to investigate how impaired placentation affects fetal development,as the growth discordance between monochorionic twins cannot be explained by confounding genetic or maternal factors.Herein,we constructed and ana-lyzed the placental proteomic profiles of IUGR twins and normal cotwins.Specifically,we identified a total of 5481 proteins,of which 233 were differentially expressed(57 up-regulated and 176 down-regulated)in IUGR twins.Bioinformatics analysis indicates that these differentially expressed proteins(DEPs)are mainly associated with cardiovascular system development and function,organismal survival,and organismal development.Notably,34 DEPs are significantly enriched in angiogenesis,and diminished placental angiogenesis in IUGR twins has been further elaborately confirmed.Moreover,we found decreased expression of metadherin(MTDH)in the placentas of IUGR twins and demonstrated that MTDH contributes to placental angiogenesis and fetal growth in vitro.Collectively,our findings reveal the comprehensive proteomic signatures of placentas for sIUGR twins,and the DEPs identified may provide in-depth insights into the pathogenesis of placental dysfunction and subsequent impaired fetal growth.

Selective intrauterine growth restrictionPlacentaProteomeAngiogenesisMetadherin

Xin-Lu Meng、Peng-Bo Yuan、Xue-Ju Wang、Jing Hang、Xiao-Ming Shi、Yang-Yu Zhao、Yuan Wei

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Department of Obstetrics and Gynecology,Peking University Third Hospital,Beijing 100191,China

Center for Reproductive Medicine,Department of Obstetrics and Gynecology,Peking University Third Hospital,Beijing 100191,China

Key Laboratory of Assisted Reproduction,Ministry of Education,Beijing 100191,China

Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction,Beijing 100191,China

National Clinical Research Center for Obstetrics and Gynecology,Beijing 100191,China

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National Natural Science Foundation of ChinaNational Natural Science Foundation of China

8197139982171661

2023

10.1016/j.gpb.2023.03.002

基因组蛋白质组与生物信息学报(英文版)
中国科学院北京基因组研究所

基因组蛋白质组与生物信息学报(英文版)

CSTPCDCSCD
影响因子：0.495
ISSN：1672-0229
年,卷(期)：2023.6(6)
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