摘要
由于基因组序列与编码基因之间数目极度不匹配,探究基因组非编码区的潜在功能具有重要意义.转座元件作为基因组非编码区最主要的组成部分,通过转位、顺式调控元件、RNA与蛋白质产物等多种方式,在DNA、RNA、蛋白质、三维基因组等多个层面影响宿主基因的生理和病理表达,从而参与肿瘤的发生发展.本文结合近年来前列腺癌方向转座元件相关的研究结果,阐述了前列腺癌基因组工作中的转座元件相关研究部分,并探讨转座元件在前列腺癌临床诊断、临床预后、临床治疗等方面的潜在应用前景.
Abstract
Due to the extreme mismatch between the number of genome sequences and coding genes,it is important to explore the po-tential functions of non-coding regions of the genome.As the most important component of the non-coding region,transposable elements affect the physiological and pathological expression of host genes through translocation,cis-regulatory elements,RNA and protein pro-ducts at multiple levels such as DNA,RNA,protein and three-dimensional genome,and thus participate in the occurrence and deve-lopment of tumors.Combined with the results of the researches on transposable elements in prostate cancer in recent years,this paper describes the transposon-related part of the prostate cancer genome work,and discusses the potential application prospect of transposon in clinical diagnosis,clinical prognosis,clinical treatment and other aspects of prostate cancer.
基金项目
国家重点研发计划青年科学家项目(2022YFA1305700)
国家自然科学基金(82022055)
国家自然科学基金(82272793)
NETL
NSTL
万方数据