Research Progress of Transposable Elements in Prostate Cancer
Due to the extreme mismatch between the number of genome sequences and coding genes,it is important to explore the po-tential functions of non-coding regions of the genome.As the most important component of the non-coding region,transposable elements affect the physiological and pathological expression of host genes through translocation,cis-regulatory elements,RNA and protein pro-ducts at multiple levels such as DNA,RNA,protein and three-dimensional genome,and thus participate in the occurrence and deve-lopment of tumors.Combined with the results of the researches on transposable elements in prostate cancer in recent years,this paper describes the transposon-related part of the prostate cancer genome work,and discusses the potential application prospect of transposon in clinical diagnosis,clinical prognosis,clinical treatment and other aspects of prostate cancer.
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