Coronary heart disease(CHD)is a complex disease with the highest mortality and disability rates worldwide.It is primarily caused by a combination of genetic and environmental factors,resulting in a diverse range of phenotypes.The genetic component signifi-cantly influences the development of coronary heart disease,and the pathological molecular mechanism is complex.It is crucial to un-derstand the susceptibility genes linked to it in order to grasp its pathogenesis.This article offers an overview of the connection between different susceptibility genes,including androgen-dependent TFPI regulating protein(ADTRP),apolipoprotein(Apo)gene family,fat factor,inflammatory cytokine,and the progression of coronary heart disease.
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