A Review for the Application of Large Language Model in Protein Design
In the field of protein design,the application of artificial intelligence technology has spawned some large models.The com-putational design of proteins refers to the process of using computer technology to assist in determining the amino acid sequence of pro-teins and achieving preset structures and functions.Computational protein design can be conducted through redesign or de novo design.The rapid generation of proteins with specific functions is of great significance to the development of biomedical research,drug develop-ment,and bioengineering.This article first provides an overview of computational protein design from traditional computational methods,machine learning methods,and deep learning methods.Then,it introduces the core architecture of large language models,Transformer,and focuses on introducing the research and application of protein large language models.Finally,it looks forward to the future research priorities.
Protein sequenceProtein structureLarge language modelTransformer architecture
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